A quiet, peaceful village of D2R Items very little importance until it is threatened by the hordes of cultists and the undead. Players then learn from Diablo fan favorite Deckard Cain that in order to bring peace in the hamlet (and then the whole world), they must travel across Sanctuary to find and destroy the shards from the Worldstone and prevent from a deadly catastrophe.

However, in the midst of that chaos is another conflict that involves the conflict between Immortals with the Shadows often referred to as"the "Cycle of Strife." According to the legends associated with the game the conflict started when a powerful woman named Daedessa the Builder gave birth to two children: Kion and Akeba.

To her son, Kion, she gifted an artifact referred to as the Eternal Crown, and bestowed on him the duty of guarding Sanctuary from the dead. In the end, Kion used his power as well as the crown to build the Immortals which is a group that focuses on protecting the world.

However, for her child Akeba, Daedessa gave an more important responsibility: to be in the shadows. She was constantly testing and challenging her brother's vigilance in order to ensure the Immortals were always deserving of their place. Akeba created an organization known as the Shadows, with the understanding that should they be able to surpass the buy D2R Ladder Items the Shadows would be Immortals themselves.